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Caspase-7 Rabbit anti-Human, Polyclonal, Bioss
SDP

Rabbit Polyclonal Antibody

Supplier:  Bioss BS3665R

Encompass_Preferred

Catalog No. 50-198-5568


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Description

Description

Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
Specifications

Specifications

Caspase-7
Polyclonal
Unconjugated
CASP7
AI314680; Apoptotic protease Mch-3; Casp7; CASP-7; caspase 7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; Cysteine protease LICE2; ICE-IAP3; ICE-LAP3; ICE-like apoptotic protease 3; Lice2; mCASP-7; Mch3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6
Rabbit
Protein A
RUO
840
-20°C
Liquid
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P55210
CASP7
KLH conjugated synthetic peptide derived from human Caspase-7.
100 μL
Primary
Human
Antibody
IgG
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