Invitrogen™ Caspr2 Recombinant Rabbit Monoclonal Antibody (2H2I5)

Catalog No.	Quantity
PIMA537891	100 μL

Catalog No. PIMA537891

Supplier: Invitrogen™ MA537891

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: Mouse spinal cord, Rat brain Immunogen sequence: HLDHLDSASA DFPYNPGQGQ AIRNGVNRNS AIIGGVIAVV IFTILCTLVF LIRYMFRHKG TYHTNEAKGA ESAESADAAI MNNDPNFTET IDESKKEWLI.

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.

Specifications

• Antigen: Caspr2
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 2H2I5
• Concentration: 0.18 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: CNTNAP2
• Gene Accession No.: Q9CPW0
• Gene Alias: 5430425M22Rik; AUTS15; CASPR2; CDFE; Cell recognition molecule Caspr2; Cntnap2; contactin associated protein-like 2; contactin-associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV; KIAA0868; mKIAA0868; NRXN4; PTHSL1
• Gene Symbols: CNTNAP2
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1232-1331 of human Caspr2/CNTNAP2 (Q9UHC6).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 500105, 66797
• Target Species: Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG