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Invitrogen™ Catenin alpha-1 Polyclonal Antibody, DyLight™ 488
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Catalog No. PIPA579091
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100 μg
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Catalog No. Quantity
PIPA579091 100 μg
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Catalog No. PIPA579091 Supplier Invitrogen™ Supplier No. PA579091
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Description

Rabbit Polyclonal Antibody

Positive Control - Flow: Hela cell.

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Catenin alpha-1
Applications Flow Cytometry
Classification Polyclonal
Concentration 200 μg/mL
Conjugate DyLight 488
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene CTNNA1
Gene Accession No. P35221
Gene Alias [a]E-catenin; 102 kDa cadherin-associated protein; 2010010M04Rik; AA517462; AI988031; alpha E catenin; alpha E-catenin; alpha(E)-catenin; alpha-E-catenin; cadherin associated protein; Cadherin-associated protein; CAP102; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha; catenin (cadherin-associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; catenin alpha 1 S homeolog; catenin alpha-1; catenin, alpha 1; Catna1; cell-adhesion protein alphaE catenin; ctnna; ctnna1; ctnna1.S; MDPT2; Renal carcinoma antigen NY-REN-13; XELAEV_18020018mg
Gene Symbols CTNNA1
Host Species Rabbit
Immunogen E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1495
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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