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Invitrogen™ Catenin alpha-1 Polyclonal Antibody

Catalog No. PIPA125081
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100 μL
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Catalog No. Quantity
PIPA125081 100 μL
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Catalog No. PIPA125081 Supplier Invitrogen™ Supplier No. PA125081

Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431 and cytosolic fraction of rat embryonic brain, MDCK, MCF-7. PA1-25081 is expected to cross react with mouse (100% conserved) and Xenopus laevis (100% conserved) due to sequence homology. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Catenin alpha-1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene CTNNA1
Gene Accession No. P26231, P35221
Gene Alias [a]E-catenin; 102 kDa cadherin-associated protein; 2010010M04Rik; AA517462; AI988031; alpha E catenin; alpha E-catenin; alpha(E)-catenin; alpha-E-catenin; cadherin associated protein; Cadherin-associated protein; CAP102; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha; catenin (cadherin-associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; catenin alpha 1 S homeolog; catenin alpha-1; catenin, alpha 1; Catna1; cell-adhesion protein alphaE catenin; ctnna; ctnna1; ctnna1.S; MDPT2; Renal carcinoma antigen NY-REN-13; XELAEV_18020018mg
Gene Symbols CTNNA1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to a region located near the C-terminus of human alpha-E-catenin (amino acids 873-887).
Purification Method IgG fraction
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12385, 1495, 307505, 474698
Target Species Human, Mouse, Rat, Canine
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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