Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ Cathelicidin/FALL-39/LL-37, Mouse, Unlabeled, Clone: 8C10.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABS1136

Catalog No. MABS1136MI


Only null left
Add to Cart

Description

Description

Cathelicidin antimicrobial peptide (UniProt P49913; also known as 18kDa cationic antimicrobial protein, CAP-18, hCAP-18) is encoded by the CAMP (also known as CAP18, FALL39, LL37) gene (ORF HSD26; Gene ID 820) in human. The human cathelicidin antimicrobial protein 18 (hCAP-18) is initially translated as a precursor molecule with a signal peptide (a.a. 1-30) and a propeptide (a.a. 31-131) sequence, the removal of which yields the mature hCAP-18 (a.a. a.a. 132-173). During the inflammatory response, hCAP-18 is proteolytically cleaved into the FALL-39 (a.a 132-170), which is further processed to yield the antimicrobial protein LL-37 (CAP-37; a.a. 134-170). Neutrophils store preformed hCAP-18 within specific granules and release it into inflamed tissue as a result of granule exocytosis. Once released, hCAP-18 is activated by proteinase-3-mediated cleavage, a component of neutrophil primary granules. In addition to its microbicidal and LPS-sequestering activity, LL-37 is also involved in the regulation of innate and humoral immune responses, wound healing, and tissue repair.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Cathelicidin/FALL-39/LL-37
Monoclonal
Please refer to lot specific datasheet.
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
P49913
KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Cathelicidin/FALL-39/LL-37.
100 μg
Signaling
NP_004336
Human
Purified
Immunohistochemistry
8C10.1
Unconjugated
CAMP, CAP18, FALL39, HSD26, LL37
Mouse
Protein G Purified
RUO
Primary
Clone 8C10.1 targets a C-terminal epitope present in the prepro- (a.a. 1-173) and pro- (a.a. 31-173) forms of hCAP-18, as well as the processed antibacterial peptides FALL-39 (a.a 132-170) and LL-37 (a.a. 134-170), but not the preprodomain (a.a. 1-131) or prodomain (a.a. 31-131) fragment.
Stable for 1 year at 2°-8°C from date of receipt.
IgG1 κ
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.

For Research Use Only. Not for use in diagnostic procedures.