Invitrogen™ Cathepsin A (Cleaved Arg326) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA576127

Catalog No. PIPA576127

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Cathepsin A, also known as protective protein/cathepsin A (PPCA), is a lysosomal serine protease encoded by the CTSA gene. It is a member of the alpha/beta hydrolase fold family, sharing structural homology with yeast carboxypeptidase Y. Cathepsin A functions predominantly in protein degradation within acidic endo/lysosomal compartments. It is involved in numerous physiological processes including intracellular protein degradation, energy metabolism, immune responses, and peptide synthesis. Particularly, the cleavage at Arg326 is significant as it pertains to its activation or functional modifications. Cathepsin A operates in conjunction with other enzymes such as neuraminidase and beta-galactosidase in a multi-enzyme complex, which is crucial for the lysosomal degradation pathways. Dysfunctions or mutations in the CTSA gene are associated with galactosialidosis, a lysosomal storage disorder characterized by a deficiency in these enzymatic activities.

Specifications

• Antigen: Cathepsin A (Cleaved Arg326)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CTSA
• Gene Alias: AU019505; beta-galactosidase 2; beta-galactosidase protective protein; carboxypeptidase C; Carboxypeptidase L; carboxypeptidase Y-like kininase; carboxypeptidase-L; cathepsin A; CTSA; deamidase; GLB2; GSL; lysosomal carboxypeptidase A; lysosomal protective protein; Lysosomal protective protein 20 kDa chain; Lysosomal protective protein 32 kDa chain; NGBE; PPCA; PPGB; protective protein cathepsin A; Protective protein for beta-galactosidase; urinary kininase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19025, 296370, 5476
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P10619, P16675
• Gene Symbols: CTSA
• Immunogen: Synthetic peptide corresponding to amino acids 291-340 of Human Cleaved-Cathepsin A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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