Invitrogen™ Cathepsin B Recombinant Rabbit Monoclonal Antibody (6I5D7)

Catalog No.	Quantity
PIMA535194	100 μL

Catalog No. PIMA535194 Supplier Invitrogen™ Supplier No. MA535194

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: SDELVNYVNK RNTTWQAGHN FYNVDMSYLK RLCGTFLGGP KPPQRVMFTE DLKLPASFDA REQWPQCPTI KEIRDQGSCG SCWAFGAVEA ISDRICIHTN AHVSVEVSAE DLLTCCGSMC GDGCNGGYPA.

Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.

Specifications

• Antigen: Cathepsin B
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: 6I5D7
• Concentration: 0.8 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Ctsb
• Gene Accession No.: P07858
• Gene Alias: amyloid precursor protein secretase; APP secretase; APPS; cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CB; CPSB; Ctsb; cysteine protease; RSG-2
• Gene Symbols: Ctsb
• Host Species: Rabbit
• Immunogen: Recombinant protein (or fragment).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1508
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG