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Invitrogen™ Cathepsin B Monoclonal Antibody (J11-A11)
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Catalog No. PIMA542576
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100 μL
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PIMA542576 100 μL
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Catalog No. PIMA542576 Supplier Invitrogen™ Supplier No. MA542576
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Description

Mouse Monoclonal Antibody

Positive Control: SW480, HepG2 Subcellular Location: Lysosome, secreted.

Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cathepsin B
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone J11-A11
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Ctsb
Gene Accession No. P07858
Gene Alias amyloid precursor protein secretase; APP secretase; APPS; cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CB; CPSB; Ctsb; cysteine protease; RSG-2
Gene Symbols Ctsb, ctsba, ctsbb
Host Species Mouse
Immunogen Synthetic peptide within human cathepsin b aa 300-338.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1508, 406645, 569298
Target Species Human, Zebrafish
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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