Invitrogen™ Cathepsin B Monoclonal Antibody (J11-A11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA542576

Catalog No. PIMA542576

Description

Positive Control: SW480, HepG2 Subcellular Location: Lysosome, secreted.

Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.

Specifications

• Antigen: Cathepsin B
• Classification: Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with 0.2% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P07858
• Gene Symbols: Ctsb, ctsba, ctsbb
• Immunogen: Synthetic peptide within human cathepsin b aa 300-338.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Zebrafish
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot, Immunocytochemistry
• Clone: J11-A11
• Conjugate: Unconjugated
• Gene: Ctsb
• Gene Alias: amyloid precursor protein secretase; APP secretase; APPS; cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CB; CPSB; Ctsb; cysteine protease; RSG-2
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1508, 406645, 569298
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid