Invitrogen™ Cathepsin B Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547975

Catalog No. PIPA547975

Description

In direct ELISAs, approximately 25% cross-reactivity with recombinant human Cathepsin B is observed and less than 5% cross-reactivity with recombinant mouse (rm) Cathepsin A, rmCathepsin C, and rmCathepsin D is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.

Specifications

• Antigen: Cathepsin B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ctsb
• Gene Alias: amyloid precursor protein secretase; APP secretase; APPS; cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CB; CPSB; Ctsb; cysteine protease; RSG-2
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13030
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Neutralization, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P10605
• Gene Symbols: Ctsb
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin B His18-Phe339.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG