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Invitrogen™ Cathepsin B Polyclonal Antibody
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Catalog No. PIPA517006
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100 μL
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Catalog No. Quantity
PIPA517006 100 μL
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Catalog No. PIPA517006 Supplier Invitrogen™ Supplier No. PA517006
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cathepsin B
Applications Western Blot
Classification Polyclonal
Concentration 26 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene Ctsb
Gene Accession No. P07858
Gene Alias amyloid precursor protein secretase; APP secretase; APPS; cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CB; CPSB; Ctsb; cysteine protease; RSG-2
Gene Symbols Ctsb
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding Gly60 of human cathepsin B.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1508
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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