Invitrogen™ Cathepsin D Monoclonal Antibody (CTD-19)

Catalog No.	Quantity
PIMA532991	100 μg

Catalog No. PIMA532991 Supplier Invitrogen™ Supplier No. MA532991

Description

Mouse Monoclonal Antibody

Reconstitute with 1 mL of PBS to yield a concentration of 100 μg/mL. Positive Control - WB: human placenta tissue, human A549 whole cell, human PC-3 whole cell, human Hela whole cell, human HepG2 whole cell, human A431 whole cell, human MCF-7 whole cell. IHC: human intestine cancer tissue, human lung cancer tissue, human mammary cancer tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Cathepsin D is a gene located on chromosome 11p15.5 that encodes a lysosomal aspartic protease involved in the degradation of proteins. This enzyme is widely expressed in various tissues but is particularly abundant in the liver, kidneys, and brain, where it plays a crucial role in intracellular protein catabolism and turnover. Cathepsin D is synthesized as an inactive precursor, procathepsin D, which is activated in the acidic environment of lysosomes. Beyond its fundamental role in protein degradation, Cathepsin D has been implicated in several physiological and pathological processes, including apoptosis, hormone processing, and antigen presentation. Dysregulation of Cathepsin D expression or activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases. In the context of cancer, Cathepsin D overexpression has been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target. Research continues to explore its diverse biological functions and therapeutic implications in various medical conditions.

Specifications

• Antigen: Cathepsin D
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: CTD-19
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Ascites, 1.2% sodium acetate with 2mg BSA and 0.01mg sodium azide
• Gene: Ctsd
• Gene Accession No.: P07339
• Gene Alias: CatD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; CathepsinD; CD; Ceroid lipofuscinosis neuronal 10; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; CTSD; epididymis secretory sperm binding protein Li 130P; HEL-S-130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692
• Gene Symbols: Ctsd
• Host Species: Mouse
• Immunogen: Human liver cathepsin D.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1509
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a