Invitrogen™ Cathepsin D Monoclonal Antibody (CTD-19)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA126773

Catalog No. MA126773

Description

Western blot detects an antigen 34kD and a weaker band at 52 kD. Suggested positive controls for this product are human breast carcinoma tissue or cell line extract.

Cathepsin D is a gene located on chromosome 11p15.5 that encodes a lysosomal aspartic protease involved in the degradation of proteins. This enzyme is widely expressed in various tissues but is particularly abundant in the liver, kidneys, and brain, where it plays a crucial role in intracellular protein catabolism and turnover. Cathepsin D is synthesized as an inactive precursor, procathepsin D, which is activated in the acidic environment of lysosomes. Beyond its fundamental role in protein degradation, Cathepsin D has been implicated in several physiological and pathological processes, including apoptosis, hormone processing, and antigen presentation. Dysregulation of Cathepsin D expression or activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases. In the context of cancer, Cathepsin D overexpression has been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target. Research continues to explore its diverse biological functions and therapeutic implications in various medical conditions.

Specifications

• Antigen: Cathepsin D
• Classification: Monoclonal
• Concentration: 5.1 mg/mL
• Formulation: Ascites with 15mM sodium azide
• Gene Accession No.: P07339
• Gene Symbols: Ctsd
• Immunogen: Purified, full length, native protein from human liver.
• Regulatory Status: RUO
• Gene ID (Entrez): 1509
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: CTD-19
• Conjugate: Unconjugated
• Gene: Ctsd
• Gene Alias: CatD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; CathepsinD; CD; Ceroid lipofuscinosis neuronal 10; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; CTSD; epididymis secretory sperm binding protein Li 130P; HEL-S-130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a