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Invitrogen™ Cathepsin F Polyclonal Antibody
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Catalog No. PIPA5100423
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PIPA5100423 100 μL
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Catalog No. PIPA5100423 Supplier Invitrogen™ Supplier No. PA5100423
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CathepsinF.

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cathepsin F
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Ctsf
Gene Accession No. Q9R013, Q9UBX1
Gene Alias AI481912; Cathepsin F; CATSF; CLN13; CTSF; HGNC:2531
Gene Symbols Ctsf
Host Species Rabbit
Immunogen A synthesized peptide derived from human CTSF(Accession Q9UBX1), corresponding to amino acid residues D330-S380.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361704, 56464, 8722
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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