Invitrogen™ Cathepsin F Polyclonal Antibody

Catalog No.	Quantity
PIPA547342	100 μg

Catalog No. PIPA547342 Supplier Invitrogen™ Supplier No. PA547342

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant mouse (rm) Cathepsin C, rmCathepsin H, and rmCathepsin L is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

Specifications

• Antigen: Cathepsin F
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: Ctsf
• Gene Accession No.: Q9R013
• Gene Alias: AI481912; Cathepsin F; CATSF; CLN13; CTSF; HGNC:2531
• Gene Symbols: Ctsf
• Host Species: Goat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin F Ser20-Asn462.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 56464
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG