Invitrogen™ Cathepsin F Polyclonal Antibody

Catalog No.	Quantity
PIPA587925	100 μL

Catalog No. PIPA587925 Supplier Invitrogen™ Supplier No. PA587925

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LAPPEWDWRS KGAVTKVKDQ GMCGSCWAFS VTGNVEGQWF LNQGTLLSLS EQELLDCDKM DKACMGGLPS NAYSAIKNLG GLETEDDYSY QGHMQSCNFS AEKAKVYIND SVELSQNEQK LAAWLAKRGP ISVAINAFGM QFYRHGISRP LRPLCSPWLI DHAVLLVGYG NRSDVPFWAI KNSWGTDWGE KGYYYLHRGS GACGVNTMAS SAVVD; Positive Samples: U-251MG, SKOV3; Cellular Location: Lysosome.

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

Specifications

• Antigen: Cathepsin F
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 2.44 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Ctsf
• Gene Accession No.: Q9UBX1
• Gene Alias: AI481912; Cathepsin F; CATSF; CLN13; CTSF; HGNC:2531
• Gene Symbols: Ctsf
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 270-484 of human CTSF (NP_0037842).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8722
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG