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Invitrogen™ Cathepsin L Monoclonal Antibody (33/1), FITC, eBioscience™
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Catalog No. 5017836
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100 Tests
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Catalog No. Quantity
50-178-36 100 Tests
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Catalog No. 50-178-36 Supplier Invitrogen™ Supplier No. BMS166FI
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Description

Mouse Monoclonal Antibody

Cathepsin L is a lysosomal cysteine proteinase consisting of a heavy chain of about 25 kDa and a light chain of about 5 kDa derived proteolytically from the same precursor. Cathepsin L has been shown to be produced by many different cell types. Since cathepsin L is capable of degrading protein constituents of the extracellular matrix it is assumed to play a crucial role in tumor progression and metastasis and a number of other disorders where the destruction of the extracellular matrix is the major cause of disease (e.g. rheumatoid arthritis, neurodegeneration). Purity: >95%. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cathepsin L
Applications Flow Cytometry
Classification Monoclonal
Clone 33/1
Concentration 10 μL/Test
Conjugate FITC
Formulation TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Gene CTSL
Gene Accession No. P07711
Gene Alias 1190035F06Rik; Cat L; cathepsin L; Cathepsin L1; Cathepsin L1 heavy chain; Cathepsin L1 light chain; CATHL; CatL; CP-2; Ctsl; CTSL1; cyclic protein 2; fs; furless; major excreted protein; MEP; nackt; nkt; p39 cysteine proteinase; Procathepsin L
Gene Symbols CTSL
Host Species Mouse
Purification Method Protein G
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1514
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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