Invitrogen™ Cathepsin L Monoclonal Antibody (33-2), eBioscience™

Catalog No.	Quantity
50-176-99	100 μg

Catalog No. 50-176-99 Supplier Invitrogen™ Supplier No. BMS1032

Description

Mouse Monoclonal Antibody

Description: Cathepsin L is a lysosomal cysteine proteinase consisting of a heavy chain of about 25 kDa and a light chain of about 5 kDa derived proteolytically from the same precursor. Cathepsin L has been shown to be produced by many different cell types. Since cathepsin L is capable of degrading protein constituents of the extracellular matrix it is assumed to play a crucial role in tumor progression and metastasis and a number of other disorders where the destruction of the extracellular matrix is the major cause of disease (e.g. rheumatoid arthritis, neurodegeneration). Applications Tested: ELISA, Immunohistochemistry (Frozen), Western Blotting.

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: Cathepsin L
• Applications: ELISA, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 33-2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.2-7.4
• Gene: CTSL
• Gene Accession No.: P07711
• Gene Alias: 1190035F06Rik; Cat L; cathepsin L; Cathepsin L1; Cathepsin L1 heavy chain; Cathepsin L1 light chain; CATHL; CatL; CP-2; Ctsl; CTSL1; cyclic protein 2; fs; furless; major excreted protein; MEP; nackt; nkt; p39 cysteine proteinase; Procathepsin L
• Gene Symbols: CTSL
• Host Species: Mouse
• Immunogen: Rec. Human Cathepsin.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1514
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1