Invitrogen™ Cathepsin L Polyclonal Antibody

Catalog No.	Quantity
PIPA588413	100 μL

Catalog No. PIPA588413 Supplier Invitrogen™ Supplier No. PA588413

Description

Rabbit Polyclonal Antibody

Immunogen sequence: APRSVDWREK GYVTPVKNQG QCGSCWAFSA TGALEGQMFR KTGRLISLSE QNLVDCSGPQ GNEGCNGGLM DYAFQYVQDN GGLDSEESYP YEATEESCKY NPKYSVANDT GFVDIPKQEK ALMKAVATVG PISVAIDAGH ESFLFYKEGI YFEPDCSSED MDHGVLVVGY GFESTESDNN KYWLVKNSWG EEWGMGGYVK MAKDRRNHCG IASAASYPTV; Positive Samples: LO2, 293T, Rat kidney; Cellular Location: Lysosome.

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: Cathepsin L
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.99 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: CTSL
• Gene Accession No.: P07154
• Gene Alias: 1190035F06Rik; Cat L; cathepsin L; Cathepsin L1; Cathepsin L1 heavy chain; Cathepsin L1 light chain; CATHL; CatL; CP-2; Ctsl; CTSL1; cyclic protein 2; fs; furless; major excreted protein; MEP; nackt; nkt; p39 cysteine proteinase; Procathepsin L
• Gene Symbols: CTSL
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 114-333 of human Cathepsin L/V/K/H (NP_0019031).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 25697
• Target Species: Rat, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG