Invitrogen™ CATSPER1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550372

Catalog No. PA550372

Description

The antibody detects endogenous levels of total CATSPER1 protein.

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

Specifications

• Antigen: CATSPER1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CATSPER1
• Gene Alias: cation channel of sperm 1; cation channel sperm associated 1; cation channel sperm-associated protein 1; cation channel, sperm associated 1; CATSPER; CATSPER1; hCatSper; KSper; sperm ion channel; sperm protein CATSPER1; sperm-associated cation channel 1; SPGF7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117144
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1.8 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q8NEC5
• Gene Symbols: CATSPER1
• Immunogen: Fusion protein corresponding to residues near the C terminal of human cation channel, sperm associated 1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG