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Invitrogen™ CATSPER3 Polyclonal Antibody
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Catalog No. PA550374
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100 μL
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PA550374 100 μL
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Catalog No. PA550374 Supplier Invitrogen™ Supplier No. PA550374
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total CATSPER3 protein.

CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins contain a single, six-transmembrane-spanning segment and exhibit the voltage-dependent Ca2+ channel four-repeat structure. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CATSPER3
Applications Western Blot
Classification Polyclonal
Concentration 1.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene CATSPER3
Gene Accession No. Q80W99, Q86XQ3
Gene Alias 4921522D01Rik; Ca(v)-like protein; CACRC; calcium channel repeat containing 1; cation channel sperm associated 3; cation channel sperm-associated protein 3; cation channel, sperm associated 3; CatSper3; One-repeat calcium channel-like protein; putative ion channel CatSper3
Gene Symbols CATSPER3
Host Species Rabbit
Immunogen Fusion protein corresponding to a region derived from internal residues of human cation channel, sperm associated 3.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 347732, 76856
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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