Invitrogen™ CATSPER3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103716

Catalog No. PIPA5103716

Description

Antibody detects endogenous levels of total CATSPER3.

CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins contain a single, six-transmembrane-spanning segment and exhibit the voltage-dependent Ca2+ channel four-repeat structure. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.

Specifications

• Antigen: CATSPER3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CATSPER3
• Gene Alias: 4921522D01Rik; Ca(v)-like protein; CACRC; calcium channel repeat containing 1; cation channel sperm associated 3; cation channel sperm-associated protein 3; cation channel, sperm associated 3; CatSper3; One-repeat calcium channel-like protein; putative ion channel CatSper3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 347732, 76856
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q80W99, Q86XQ3
• Gene Symbols: CATSPER3
• Immunogen: A synthesized peptide derived from human CATSPER3(Accession Q86XQ3), corresponding to amino acid residues L183-Q233.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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