CaV1.2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA577297

Catalog No. PIPA577297

Description

Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt. Reconstitute with 50uL deionized water.

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

Specifications

• Antigen: CaV1.2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CACNA1C
• Gene Alias: alpha1C, Cacna1c
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12288, 24239, 775
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P22002, Q01815, Q13936
• Gene Symbols: Cacna1c
• Immunogen: Peptide (C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat Cav 1.2
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG