CaV1.2 Polyclonal Antibody, Invitrogen™

Guinea Pig Polyclonal Antibody

Supplier:  Thermo Scientific PA5111791

Catalog No. PIPA5111791

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: (C)TTKINMD DLQPSENEDK S Homology: Mouse amino acid residues identical; guinea pig - 17/18 amino acid residues identical; human, rabbit - 16/18 amino acid residues identical.

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

Specifications

• Antigen: CaV1.2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CACNA1C
• Gene Alias: CACB-receptor; Cach2; CACH3; Cacn2; CACN4; CACNA 1D; CACNA1C; Cacnl1a1; CACNL1A2; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; CaV1.2; CCHL1A1; D930026N18Rik; DHP receptor; I79_006562; long-NT; LQT8; LTCC; MBC; MELC-CC; MGC120730; Mouse brain class C; Rat brain class C; RATIVS302; RBC; Smooth muscle calcium channel blocker receptor; TS; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2
• Host Species: Guinea Pig
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12288, 24239, 775
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P22002, Q01815, Q13936
• Gene Symbols: CACNA1C
• Immunogen: Peptide corresponding to amino acid residues 848-865 of rat CaV1.2 (Intracellular loop between domains II and III)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG