Invitrogen™ CaV1.3 Monoclonal Antibody (S48), APC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545391

Catalog No. PIMA545391

Description

1 μg/mL of MA5-45391 was sufficient for detection of Cav1.3 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 250kDa. No cross-reactivity against Cav1.2.

CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CaV1.3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
• Gene Accession No.: P27732, Q01668, Q99246
• Gene Symbols: CACNA1D
• Immunogen: Fusion protein amino acids 859-875 of rat Cav1.3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
• Clone: S48
• Conjugate: APC
• Gene: CACNA1D
• Gene Alias: 8430418G19Rik; brain class D; C79217; Cach3; Cacn4; CACNA 1D; CACNA1D; Cacnl1a2; calcium channel alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide isoform 2; Calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; calcium channel, voltage-dependent, L type, alpha 1D subunit; calcium voltage-gated channel subunit alpha1 D; Cav1.3; CaV1.3alpha1; Cchl1a; CCHL1A2; D-LTCC; PASNA; Rat brain class D; RBD; SANDD; voltage-dependent calcium channel subunit alpha1D; voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; voltage-gated calcium channel subunit alpha Cav1.3
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 12289, 29716, 776
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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