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CaV2.1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA577295
Description
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt. Reconstitute by adding 50 uL deionized water.
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predomitly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
Specifications
CaV2.1 | |
Polyclonal | |
Unconjugated | |
CACNA1A | |
alpha1A, Cacna1a | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
12286, 25398, 773 | |
-20°C | |
Lyophilized |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot | |
0.8 mg/mL | |
PBS with 1% BSA and 0.05% sodium azide; pH 7.4 | |
O00555, P54282, P97445 | |
CACNA1A | |
Peptide (C)PSSPERAPGREGPYGRE, corresponding to amino acid residues 865-881 of rat CaV 2.1 | |
50 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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