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Invitrogen™ CaV3.1 Monoclonal Antibody (N178A/9), APC
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Catalog No. PIMA545543
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100 μg
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PIMA545543 100 μg
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Catalog No. PIMA545543 Supplier Invitrogen™ Supplier No. MA545543
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45543 was sufficient for detection of Cav3.1 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately <200kDa. Does not cross-react with Cav3.2. This antibody was formerly sold as clone S178A-9.

Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca2+ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca2+ current types. T-type Ca2+ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CaV3.1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N178A/9
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
Gene CACNA1G
Gene Accession No. O43497, O54898
Gene Alias [a]1G; a1G; alpha-1G; Ca(V)T.1; CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit; calcium voltage-gated channel subunit alpha1 G; CaV T1; Cav3 1; cav3 1c; Cav3.1; Cav3.1c; Cav3.1d; KIAA1123; MGC117234; mKIAA1123; NBR13; SCA42; voltage-dependent calcium channel alpha 1G subunit, isoform 11; voltage-dependent T-type calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-gated calcium channel subunit alpha Cav3.1
Gene Symbols CACNA1G
Host Species Mouse
Immunogen Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12291, 29717, 8913
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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