Invitrogen™ CaV3.1 Monoclonal Antibody (N178A/9), APC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545543

Catalog No. PIMA545543

Description

1 μg/mL of MA5-45543 was sufficient for detection of Cav3.1 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately <200kDa. Does not cross-react with Cav3.2. This antibody was formerly sold as clone S178A-9.

Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca2+ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca2+ current types. T-type Ca2+ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).

Specifications

• Antigen: CaV3.1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
• Gene Accession No.: O43497, O54898
• Gene Symbols: CACNA1G
• Immunogen: Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: N178A/9
• Conjugate: APC
• Gene: CACNA1G
• Gene Alias: [a]1G; a1G; alpha-1G; Ca(V)T.1; CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit; calcium voltage-gated channel subunit alpha1 G; CaV T1; Cav3 1; cav3 1c; Cav3.1; Cav3.1c; Cav3.1d; KIAA1123; MGC117234; mKIAA1123; NBR13; SCA42; voltage-dependent calcium channel alpha 1G subunit, isoform 11; voltage-dependent T-type calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-gated calcium channel subunit alpha Cav3.1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 12291, 29717, 8913
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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