Invitrogen™ Caveolin 1 Monoclonal Antibody (7C8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA140241

Catalog No. 01-676-574

Description

MA1-40241 detects Caveolin-1 from rat samples. MA1-40241 recognizes caveolin-1 alpha as well as caveolin-1 beta, which are present in many tissues, like aorta, heart, muscle, lung, adipose white, brown and epidydimal fat. MA1-40241 can be used to immuno-isolate caveolae. MA1-40241 has been successfully used in immunofluorescence, immunoprecipitation and Western blot applications. The MA1-40241 immunogen is rat caveolin. Positive control: Adipocytes (3T3-L1 adipocytes); Negative control: Cytoplasmic extracts of adipocytes.

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

Specifications

• Antigen: Caveolin 1
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene Accession No.: P41350
• Gene Symbols: CAV1
• Immunogen: Rat caveolin-1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 7C8
• Conjugate: Unconjugated
• Gene: CAV1
• Gene Alias: BSCL3; CAV; CAV1; Cav-1; caveolae; caveolin 1; caveolin 1, caveolae protein; caveolin 1, caveolae protein, 22kDa; caveolin 1a; caveolin 1b; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; caveolin-1; caveolin-1a; caveolin-1b; cell growth-inhibiting protein 32; CGL3; HGNC:1527; LCCNS; MSTP085; OTTHUMP00000196475; PPH3; Unknown (protein for IMAGE:7985573); variant a; variant b; vesicular integral-membrane protein VIP21; VIP21; wu:fc07c04
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 25404
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov