Invitrogen™ Caveolin 1 Monoclonal Antibody (7C8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA3600

Catalog No. 01-950-138

Description

MA3-600 detects caveolin from human, rat and hamster samples. MA3-600 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a 19-21 kDa band from transfected HEK293 (B8) cells, with a non-specific band appearing at 65-70 kDa. The MA3-600 immunogen is intercellular membrane protein-containing vesicles obtained from rat.

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

Specifications

• Antigen: Caveolin 1
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.05% sodium azide
• Gene Accession No.: P41350, Q03135
• Gene Symbols: CAV1
• Immunogen: Intercellular membrane protein-containing vesicles (containing GLUT4) from rat.
• Regulatory Status: RUO
• Gene ID (Entrez): 100753021, 25404, 857
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 7C8
• Conjugate: Unconjugated
• Gene: CAV1
• Gene Alias: BSCL3; CAV; CAV1; Cav-1; caveolae; caveolin 1; caveolin 1, caveolae protein; caveolin 1, caveolae protein, 22kDa; caveolin 1a; caveolin 1b; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; caveolin-1; caveolin-1a; caveolin-1b; cell growth-inhibiting protein 32; CGL3; HGNC:1527; LCCNS; MSTP085; OTTHUMP00000196475; PPH3; Unknown (protein for IMAGE:7985573); variant a; variant b; vesicular integral-membrane protein VIP21; VIP21; wu:fc07c04
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Hamster
• Product Type: Antibody
• Isotype: IgG1