Invitrogen™ Caveolin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585274

Catalog No. PIPA585274

Description

Keep as concentrated solution. Predicted reactivity: Dog (100%), Rhesus Monkey (100%), Bovine (100%). Positive Control: Rat muscle, mouse muscle. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Caveolin-3 (CAV3) acts as a scaffolding protein within the caveolar membrane. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-3 may also regulate voltage-gated potassium channels. It also plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Caveolin-3 also mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Mutations in the gene can result in HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.

Specifications

• Antigen: Caveolin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cav3
• Gene Alias: AI385751; CAV; Cav3; Cav-3; caveolin 3; caveolin-3; LGMD1C; LQT9; M-cav; M-caveolin; MGC126100; MGC126101; MGC126129; structural protein; VIP21; VIP-21
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12391, 29161, 859
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P51637, P51638, P56539
• Gene Symbols: Cav3
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Caveolin 3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG