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  5. R&D Systems™ CB-103

R&D Systems™ CB-103
SDP

Catalog No. RD10188024 Shop All Novus Products
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RD10188024 10 mg
RD10187996 50 mg
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Catalog No. RD10188024 Supplier R&D Systems™ Supplier No. 9002/10

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Description

A Tocris product, part of R&D Systems. pan-Notch inhibitor; also inhibits differentiation of mural cells by downregulating Notch pathway.

CB-103 is a highly specific protein-protein interaction (PPI) inhibitor that interferes with the interaction between the active intracellular domains of Notch receptors (NICD) and the CSL transcription factor complex. In combination with ICI 182,780 (Cat. No. 1047), CB-103 arrests the growth of mouse xenografts. In mouse models, it displays potent tumor growth inhibition and delayed tumor relapse when combined with Taxol (Cat. No. 1097). CB-103 inhibits differentiation of mural cells by downregulating Notch pathway. CB-103 is orally bioavailable.

Specifications

Chemical Name or Material 6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine
CAS 218457-67-1
Quantity 10 mg
Product Line Tocris
Target Notch Signaling Inhibitors
Molecular Formula C15H18N2O
Purity 98%
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