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  5. Tocris Bioscience™ CB 5083

Tocris Bioscience™ CB 5083
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Catalog No. 737925
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Quantity:
5 mg
25 mg
Catalog No. Quantity
73-792-5 25 mg
73-795 5 mg
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Catalog No. 73-792-5

Supplier: Tocris Bioscience™ 7379/25

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Description

Potent p97 ATPase inhibitor

CB 5083 is a potent p97 inhibitor, inhibiting the D2 ATPase domain (IC50 = 11 nM). CB 5083 shows broad antitumor activity and inhibits tumor growth in vivo. CB 5083 is cytotoxic to A549 cancer cells (IC50 = 680 nM), increases CHOP and GRP78 protein levels and results in the loss of aggresomes.

Specifications

Chemical Name or Material 1-[7,8-Dihydro-4-[(phenylmethyl)amino]-5 H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1 H-indole-4-carboxamide
CAS 1542705-92-9
Quantity 25 mg
Target p97 ATPase Inhibitors
Molecular Formula C24H23N5O2
Purity 0.98
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