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Invitrogen™ CBF beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528505

Catalog No. PIPA528505


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Description

Description

Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (85%), Xenopus laevis (92%), Cat (100%), Chicken (96%), Rhesus Monkey (97%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CBF beta
Polyclonal
Unconjugated
CBFB
AI893578; CBFB; CBF-beta; core binding factor beta; core-binding factor subunit beta; core-binding factor, beta subunit; PEA2; PEA2-beta; Pebp2; PEBP2B; PEBP2-beta; Pebpb2; polyomavirus enhancer binding protein 2, beta subunit; polyomavirus enhancer-binding protein 2 beta subunit; SL3/AKV core-binding factor beta subunit; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta
Rabbit
Antigen affinity chromatography
RUO
865
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q13951
CBFB
Recombinant fragment corresponding to a region within amino acids 1 and 182 of Human PEBP2beta.
100 μL
Primary
Human
Antibody
IgG
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