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Cbl-b Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501563773
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50-156-3773 100 μL
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Catalog No. 50-156-3773 Supplier Bethyl Laboratories, Inc Supplier No. A302903A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

Specifications

Antigen Cbl-b
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene CBLB
Gene Accession No. Q13191
Gene Alias Cbl-b, RNF56, Cas-Br-M (murine) ectropic retroviral transforming sequence b, E3 ubiquitin-protein ligase CBL-B, RING finger protein 56, SH3-binding protein CBL-B, casitas B-lineage lymphoma proto-oncogene b, signal transduction protein CBL-B
Gene Symbols CBLB
Host Species Rabbit
Immunogen Between 932 and 982
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 868
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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