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CBLC Monoclonal Antibody (OTI3B4), TrueMAB™, OriGene

Mouse Monoclonal Antibody
Supplier: OriGene TA505071

Description
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at ′Tyr-419′. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.Specifications
CBLC | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
Q9ULV8 | |
CBLC | |
Human recombit protein fragment corresponding to amino acids 244-474 of human CBLC produced in E.coli. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG2b |
Flow Cytometry, Western Blot | |
OTI3B4 | |
Unconjugated | |
CBLC | |
CBL-3, CBL-SL, RNF57 | |
Mouse | |
Affinity Chromatography | |
RUO | |
23624 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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