CBLC Monoclonal Antibody (OTI3B4), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA505071

Catalog No. 50-167-5619

Description

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at ′Tyr-419′. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Specifications

• Antigen: CBLC
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9ULV8
• Gene Symbols: CBLC
• Immunogen: Human recombit protein fragment corresponding to amino acids 244-474 of human CBLC produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Western Blot
• Clone: OTI3B4
• Conjugate: Unconjugated
• Gene: CBLC
• Gene Alias: CBL-3, CBL-SL, RNF57
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23624
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid