CBLC Mouse anti-Human, Clone: OTI3D9, lyophilized, TrueMAB™

Catalog No.	Quantity
50-166-3347	100 μg

Catalog No. 50-166-3347 Supplier OriGene Supplier No. CF505052

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at ′Tyr-419′. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Specifications

• Antigen: CBLC
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI3D9
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: CBLC
• Gene Accession No.: Q9ULV8
• Gene Alias: CBL-3, CBL-SL, RNF57
• Gene Symbols: CBLC
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 244-474 of human CBLC produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23624
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1