CBLC Mouse anti-Human, Clone: OTI3D9, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF505052

Catalog No. 50-166-3347

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at ′Tyr-419′. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Specifications

• Antigen: CBLC
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CBLC
• Gene Alias: CBL-3, CBL-SL, RNF57
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23624
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI3D9
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9ULV8
• Gene Symbols: CBLC
• Immunogen: Human recombit protein fragment corresponding to amino acids 244-474 of human CBLC produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1