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CBLN4 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981692
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50-198-1692 100 μL
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Catalog No. 50-198-1692 Supplier Bioss Supplier No. BS11816R
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Description

Rabbit Polyclonal Antibody

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other′s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.

Specifications

Antigen CBLN4
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene CBLN4
Gene Accession No. Q9NTU7
Gene Alias AI848962; CBLN4; CBLNL1; cerebellin 4 precursor; cerebellin 4 precursor protein; cerebellin precursor-like 1; Cerebellin4; Cerebellin-4; Cerebellin-like glycoprotein 1; UNQ718/PRO1382
Gene Symbols CBLN4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CBLN4.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140689
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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