Invitrogen™ CBP/p300 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599492

Catalog No. PIPA599492

Description

Antibody detects endogenous levels of total P300/CBP.

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: CBP/p300
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EP300
• Gene Alias: A430090G16; A730011L11; AW558298; CBP; CBP/p300; CREB binding protein; CREB-binding protein; Crebbp; E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; KAT3A; KAT3B; p300; p300 HAT; p300/CBP; Protein propionyltransferase p300; RSTS; RSTS2; RTS
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12914, 1387, 170915, 2033, 328572, 54244
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: B2RWS6, P45481, Q09472, Q6JHU9, Q92793
• Gene Symbols: CREBBP, EP300
• Immunogen: A synthesized peptide derived from human EP300(Accession Q09472), corresponding to amino acid residues K1549-R1599.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG