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  5. Tocris Bioscience™ CBR-470-1

Tocris Bioscience™ CBR-470-1
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Catalog No. 701850
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70-185-0 50 mg
70-181-0 10 mg
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Catalog No. 70-185-0 Supplier Tocris Bioscience™ Supplier No. 7018/50
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Description

PGK1 inhibitior; activates Nrf2

CBR-470-1 is a phosphoglycerate kinase 1 (PGK1) inhibitor. CBR-470-1 promotes accumulation of the reactive metabolites methylglyoxal (MGO) resulting in KEAP1 modification and dimerization, which in turn leads to activation of the Nrf2 transcriptional program. CBR-470-1 protects SH-SY5Y neuroblastoma cells from MPP+-induced cytotoxicity via the Keap1-Nrf2 cascade.

Specifications

Chemical Name or Material (3 R,4 S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
CAS 2416095-06-0
Quantity 50 mg
Target Nrf2 Activators
Molecular Formula C14H20ClNO4S2
Purity 98%
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