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Invitrogen™ CBX4 Polyclonal Antibody
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Catalog No. PIPA5114949
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100 μL
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PIPA5114949 100 μL
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Catalog No. PIPA5114949 Supplier Invitrogen™ Supplier No. PA5114949
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CBX4.

Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CBX4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene CBX4
Gene Accession No. O00257, O55187
Gene Alias Cbx4; chromobox 4; chromobox homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; E3 SUMO-protein transferase CBX4; hPc2; MPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; Polycomb 2 homolog
Gene Symbols CBX4
Host Species Rabbit
Immunogen A synthesized peptide derived from human CBX4(Accession O00257), corresponding to amino acid residues T94-P144.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12418, 501403, 8535
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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