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Invitrogen™ CBX4 Polyclonal Antibody
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Catalog No. PIPA5110742
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PIPA5110742 100 μL
PIPA5110770 100 μL
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Catalog No. PIPA5110742 Supplier Invitrogen™ Supplier No. PA5110742
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SPKYNTWEPE ENILDPRLLI AFQNRERQEQ LMGYRKRGPK PKPLVVQVPT FARRSNVLTG LQDSSTDNRA KLDSGAEEK Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.

Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CBX4
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.20 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CBX4
Gene Accession No. O00257
Gene Alias Cbx4; chromobox 4; chromobox homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; E3 SUMO-protein transferase CBX4; hPc2; MPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; Polycomb 2 homolog
Gene Symbols CBX4
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human CBX4. Recombinant protein control fragment (Product #RP-89355).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8535
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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