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Invitrogen™ CCDC114 Polyclonal Antibody
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Catalog No. PIPA560012
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100 μL
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PIPA560012 100 μL
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Catalog No. PIPA560012 Supplier Invitrogen™ Supplier No. PA560012
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SKDDQHLLQE QQQKVLQQRM DKVHSEAERL EARFQDVRGQ LEKLKADIQL LFTKAHCDSS MIDDLLGVKT SMGDRDMGLF LSLIEKRLVE Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 70%.

The CCDC114 gene, located on chromosome 19, encodes a protein that is a key component of the structure and function of cilia, which are hair-like organelles present on the surface of many cell types. Structurally, CCDC114 belongs to the coiled-coil domain-containing family, which plays crucial roles in cellular organizations and motility. Functionally, CCDC114 is involved in forming the outer dynein arm of cilia, essential for their motility. Mutations in CCDC114 can lead to defects in ciliary structure, resulting in primary ciliary dyskinesia (PCD), a condition characterized by chronic respiratory tract infections, abnormal organ positioning, and other symptoms. Specifically, mutations like c.742G>A and c.584T>C have been identified to cause variant forms of PCD, as well as situs inversus, which is a complete mirror image reversal of the body's internal organ arrangement. Genetic investigations have shown that these mutations can significantly disrupt the function of cilia, confirming CCDC114's critical role in human ciliopathies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCDC114
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CCDC114
Gene Accession No. Q96M63
Gene Alias Ccdc114; CILD20; coiled-coil domain containing 114; coiled-coil domain-containing protein 114; RGD1308141
Gene Symbols CCDC114
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CCDC114. Recombinant protein control fragment (Product #RP-98955).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 93233
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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