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Invitrogen™ CCDC127 Polyclonal Antibody
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Catalog No. PIPA560912
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100 μL
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PIPA560912 100 μL
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Catalog No. PIPA560912 Supplier Invitrogen™ Supplier No. PA560912
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RRTAAFQQDL EAKYHAMISE NRRAVAQLSL ELEKEQNRTA SYREALISQG RKLVEEKKLL EQERAQVMQE KRQVQPLRSA YLSCLQREEN WQRR Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 82%.

CCDC127 (Coiled-Coil Domain-Containing 127) is a gene that has been identified as a key regulator of lipid droplet (LD) homeostasis by enhancing the mitochondria-ER contact sites (MERCS). This gene encodes a protein with coiled-coil domains, which facilitate interactions with other proteins and cellular structures. CCDC127 plays a critical role in the formation and maintenance of LDs, which are essential organelles for storing neutral lipids and are involved in lipid metabolism and energy homeostasis. Knockdown and overexpression studies in HeLa cells have shown that CCDC127 positively regulates LD abundance, suggesting its importance in cellular lipid management. Additionally, it has been observed that CCDC127 impacts adipose differentiation, indicating its broader role in lipid biology and potential implications in metabolic diseases. The ability of CCDC127 to modulate MERCS highlights its significance in cellular lipid dynamics and organelle communication.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCDC127
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CCDC127
Gene Accession No. Q96BQ5
Gene Alias 0610011N22Rik; 5430420E17Rik; A430066A18; AI256405; AW050060; C130002N06; CCDC127; coiled-coil domain containing 127; coiled-coil domain-containing protein 127; RGD735106
Gene Symbols CCDC127
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CCDC127. Recombinant protein control fragment (Product #RP-97600).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 133957
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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