Invitrogen™ CCDC127 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113214

Catalog No. PIPA5113214

Description

CCDC127 Polyclonal Antibody for Western Blot, ELISA

CCDC127 (Coiled-Coil Domain-Containing 127) is a gene that has been identified as a key regulator of lipid droplet (LD) homeostasis by enhancing the mitochondria-ER contact sites (MERCS). This gene encodes a protein with coiled-coil domains, which facilitate interactions with other proteins and cellular structures. CCDC127 plays a critical role in the formation and maintenance of LDs, which are essential organelles for storing neutral lipids and are involved in lipid metabolism and energy homeostasis. Knockdown and overexpression studies in HeLa cells have shown that CCDC127 positively regulates LD abundance, suggesting its importance in cellular lipid management. Additionally, it has been observed that CCDC127 impacts adipose differentiation, indicating its broader role in lipid biology and potential implications in metabolic diseases. The ability of CCDC127 to modulate MERCS highlights its significance in cellular lipid dynamics and organelle communication.

Specifications

• Antigen: CCDC127
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCDC127
• Gene Alias: 0610011N22Rik; 5430420E17Rik; A430066A18; AI256405; AW050060; C130002N06; CCDC127; coiled-coil domain containing 127; coiled-coil domain-containing protein 127; RGD735106
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 133957, 67433
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q3TC33, Q96BQ5
• Gene Symbols: CCDC127
• Immunogen: Recombinant Human Coiled-coil domain-containing protein 127 protein (1-260AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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