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Invitrogen™ CCDC151 Polyclonal Antibody
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Catalog No. PIPA562991
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100 μL
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PIPA562991 100 μL
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Catalog No. PIPA562991 Supplier Invitrogen™ Supplier No. PA562991
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LLDLLKGDEK VVQAVIREWK WEKPYLKNRT GQALEHLDHR LREKVKQQNA LRHQVVLRQR RLEELQLQHS LRLLEMAEAQ NRHTEVAKTM RNLE Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 76%.

CCDC151 (Coiled-Coil Domain-Containing 151) is a gene located on chromosome 19p13.2 that encodes a protein essential for the assembly and function of motile cilia. The protein is highly conserved across species with motile cilia and is the vertebrate ortholog of the Chlamydomonas ODA10 gene. CCDC151 is crucial for the assembly and docking of outer dynein arms (ODAs) on the axoneme of cilia, which are necessary for ciliary beating and motility. Mutations in CCDC151 have been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory infections, abnormal organ positioning (situs inversus), and infertility due to defective ciliary movement. Studies in zebrafish and mouse models have demonstrated that mutations in CCDC151 lead to a spectrum of situs defects and complex heart abnormalities. These findings underscore the pivotal role of CCDC151 in ciliary function and its implications in human health and disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCDC151
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CCDC151
Gene Accession No. A5D8V7
Gene Alias CCDC151; CILD30; coiled-coil domain containing 151; coiled-coil domain-containing protein 151
Gene Symbols CCDC151
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CCDC151. Recombinant protein control fragment (Product #RP-104275).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 115948
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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