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Invitrogen™ CCDC151 Polyclonal Antibody

Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA532041
Description
Recommended positive controls: A431, HeLa. Predicted reactivity: Chimpanzee (98%), Bovine (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CCDC151 (Coiled-Coil Domain-Containing 151) is a gene located on chromosome 19p13.2 that encodes a protein essential for the assembly and function of motile cilia. The protein is highly conserved across species with motile cilia and is the vertebrate ortholog of the Chlamydomonas ODA10 gene. CCDC151 is crucial for the assembly and docking of outer dynein arms (ODAs) on the axoneme of cilia, which are necessary for ciliary beating and motility. Mutations in CCDC151 have been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory infections, abnormal organ positioning (situs inversus), and infertility due to defective ciliary movement. Studies in zebrafish and mouse models have demonstrated that mutations in CCDC151 lead to a spectrum of situs defects and complex heart abnormalities. These findings underscore the pivotal role of CCDC151 in ciliary function and its implications in human health and disease.
Specifications
CCDC151 | |
Polyclonal | |
Unconjugated | |
CCDC151 | |
CCDC151; CILD30; coiled-coil domain containing 151; coiled-coil domain-containing protein 151 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
115948 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
A5D8V7 | |
CCDC151 | |
Recombinant protein encompassing a sequence within the center region of human CCDC151. The exact sequence is proprietary. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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