Invitrogen™ CCDC79 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA571009

Catalog No. PIPA571009

Description

This target displays homology in the following species: Human: 100%.

Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.

Specifications

• Antigen: CCDC79
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TERB1
• Gene Alias: CCDC79; coiled-coil domain containing 79; coiled-coil domain-containing protein 79; telomere repeat binding bouquet formation protein 1; telomere repeats-binding bouquet formation protein 1; TERB1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 283847
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8NA31
• Gene Symbols: TERB1
• Immunogen: synthetic peptide directed towards the C-terminal region of human CCDC79.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG