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Invitrogen™ CCDC79 Polyclonal Antibody
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Catalog No. FEPA5145214
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100 μL
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FEPA5145214 100 μL
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Catalog No. FEPA5145214 Supplier Invitrogen™ Supplier No. PA5145214
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NYQDNISSMN ISIQNTWKHL HADRIGRGSK AEDEDKSHSR QLQSYKSHGV MSKACTNDDQ MKTPLKSANP VHACYRESEQ NKTLYKAKSS CNQN Antigen sequence identity: Mouse 46%; Rat 49%.

Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCDC79
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TERB1
Gene Accession No. Q8NA31
Gene Alias CCDC79; coiled-coil domain containing 79; coiled-coil domain-containing protein 79; telomere repeat binding bouquet formation protein 1; telomere repeats-binding bouquet formation protein 1; TERB1
Gene Symbols TERB1
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 431-524.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 283847
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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