Invitrogen™ CCDC91 Polyclonal Antibody

Catalog No.	Quantity
PIPA558280	100 μL

Catalog No. PIPA558280 Supplier Invitrogen™ Supplier No. PA558280

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MDDDDFGGFE AAETFDGGSG ETQTTSPAIP WAAFPAVSGV HLSPSSPEIV LDRDHSSSIG CLSSDAIISS PENTHAANSI VSQTIPKAQ Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 69%.

CCDC91 (Coiled-Coil Domain-Containing 91) is a gene located on chromosome 12q24.31 that encodes a protein involved in vesicle-mediated transport and Golgi function. The CCDC91 protein contains coiled-coil domains, which facilitate protein-protein interactions necessary for its role in the secretory pathway. Specifically, CCDC91 is a component of the Golgi-associated retrograde protein (GARP) complex, which is essential for the recycling of transport vesicles from endosomes to the trans-Golgi network (TGN). Research has revealed that CCDC91 is crucial for maintaining Golgi structure and function and is involved in the sorting and trafficking of proteins and lipids within the cell. The protein's interactions with other components of the vesicular transport machinery enable the efficient movement of cargo between organelles, which is critical for various cellular processes, including secretion, endocytosis, and lysosomal degradation. Mutations or dysregulation of CCDC91 can disrupt these processes, potentially leading to diseases associated with vesicle trafficking defects, such as certain neurodegenerative disorders and cancer.

Specifications

• Antigen: CCDC91
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: CCDC91
• Gene Accession No.: Q7Z6B0
• Gene Alias: 1700086G08Rik; 1810060J02Rik; AU045683; AW555238; Ccdc91; coiled-coil domain containing 91; coiled-coil domain-containing protein 91; GGA binding partner; GGA-binding partner; Ggabp; HSD8; p56; p56 accessory protein
• Gene Symbols: CCDC91
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human CCDC91. Recombinant protein control fragment (Product #RP-97723).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55297
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG