Invitrogen™ CCL19 Polyclonal Antibody

Catalog No.	Quantity
PIPA578936	100 μg

Catalog No. PIPA578936 Supplier Invitrogen™ Supplier No. PA578936

Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat thymus tissue, rat lung tissue, rat spleen tissue, rat stomach tissue, rat PC-12 whole cell, mouse thymus tissue, mouse NIH3T3 whole cell.

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.

Specifications

• Antigen: CCL19
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene: Ccl19
• Gene Accession No.: O70460
• Gene Alias: beta chemokine exodus-3; beta-chemokine exodus-3; CC chemokine ligand 19; C-C motif chemokine; C-C motif chemokine 19; C-C motif chemokine ligand 19; Ccl19; chemokine (C-C motif) ligand 19; chemokine CCL19; CK beta-11; CKb11; EBI1 ligand chemokine; EBI-1 ligand chemokine; EBI1-ligand chemokine; EBV-induced molecule 1 ligand chemokine; ELC; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP3B; MIP-3b; MIP-3-beta; M-MIP-3-beta; SCYA19; small inducible cytokine A19; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19
• Gene Symbols: Ccl19
• Host Species: Rabbit
• Immunogen: E. coli-derived rat Ccl19/MIP-3 beta recombinant protein (Position: G26-S108).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 24047, 362506
• Target Species: Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG