CCL2 (MCP-1) Monoclonal Antibody (2H5), Functional Grade, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
16-709-638	Invitrogen™ 16709638	5 mg

Description

The 2H5 MAb reacts with mouse, rat, and human monocyte chemoattractant protein-1 (MCP-1), also known as CCL2 and MCAF.

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Specifications

• Antigen: CCL2 (MCP-1)
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with no preservative; pH 7.2
• Gene ID (Entrez): 20296, 24770, 6347
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Gene: Ccl2

• Clone: 2H5
• Applications: Functional Assay, Neutralization
• Conjugate: Functional Grade
• Host Species: Armenian Hamster
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P10148, P13500, P14844
• Isotype: IgG
• Purification Method: Affinity chromatography
• Product Type: Antibody